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RNA-Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications 期刊论文

编号：

70318C97F8764E50024B5AADFD9BF1E2
作者：

Chang, Linlin#^[1,2,3]Lu, Bin^[4,5,6];Shang, Haotian^[7];Ding, Wanjing^[8];Wei, Chunhua^[2,9];Qi, Xiaotian^[10];He, Pengxing*^[1,2,3,7]
语种：

英文
期刊：

MEDCOMM-ONCOLOGY ISSN：2769-6448 2026 年 5 卷 1 期 ; JAN 26
收录：
关键词：

clinical potentials ferroptosis RNA-binding proteins small molecules
摘要：

Ferroptosis is a regulated, iron-dependent form of cell death that has emerged as a promising therapeutic target for multiple cancers. However, its clinical translation faces significant challenges, particularly regarding precision and safety for cancer patients. Recent studies have identified RNA-binding proteins (RBPs) as novel regulators of tumor ferroptosis, extending beyond the established biochemical hallmarks and core defense mechanisms of ferroptosis. This review focuses on the core machinery of ferroptosis and the canonical functions of RBPs in cancer biology. We further present evidence demonstrating that RBPs play a critical role in coordinating iron, lipid, and amino acid metabolism to influence ferroptosis, highlighting the complex interplay between RBPs and ferroptotic processes. Building on these insights, we explore therapeutic opportunities targeting the RBP-ferroptosis axis from three perspectives: small molecules, synthetic lethality strategies, and drug delivery systems. Finally, we discuss the challenges and future prospects of RBP-based ferroptosis therapeutic strategies in cancer. Overall, this review underscores the significant role of RBPs in tumor ferroptosis and lays the groundwork for precision oncology approaches guided by ferroptosis, moving beyond the classical biochemical hallmarks and core defense systems.
推荐引用方式
GB/T 7714：

Chang Linlin,Lu Bin,Shang Haotian, et al. RNA-Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications [J].MEDCOMM-ONCOLOGY,2026,5(1).
APA：

Chang Linlin,Lu Bin,Shang Haotian,Ding Wanjing,&He Pengxing.(2026).RNA-Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications .MEDCOMM-ONCOLOGY,5(1).
MLA：

Chang Linlin, et al. "RNA-Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications" .MEDCOMM-ONCOLOGY 5,1(2026).
入库时间：

3/25/2026 9:57:12 PM
更新时间：

3/25/2026 9:57:12 PM

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