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Natural medicine HLXL targets multiple pathways of amyloid-mediated neuroinflammation and immune response in treating alzheimer''s disease 期刊论文

编号：

996C0BE153F5E781A5BDE58C5DE75667
作者：

Liang, Yingxia(梁映霞)#^[1,2,3]Lee, David Y. W.*^[4,5]Zhen, Sherri^[1,2];Sun, Haoqi^[2,6];Zhu, Biyue^[2,7];Liu, Jing^[4,5,9];Lei, Dan^[1];Lin, ChihChung Jerry^[1,2];Zhang, Siyi^[1,2];Jacques, Nicholas A.^[1,2];Quinti, Luisa^[1,2];Ran, Chongzhao^[2,7]Wang, Changning^[2,7]Griciuc, Ana^[1,2];Choi, Se Hoon^[1,2]Dai, Rong Hua(戴荣华)^[4,5,9]Efferth, Thomas^[8]Tanzi, Rudolph E.*^[1,2]Zhang, Can*^[1,2]
语种：

英文
期刊：

PHYTOMEDICINE ISSN：0944-7113 2022 年 104 卷 ; SEP
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关键词：

Alzheimer?s disease Natural medicine HlXL Neuroinflammation Innate immune response
摘要：

Background: Based on the complex pathology of AD, a single chemical approach may not be sufficient to deal simultaneously with multiple pathways of amyloid-tau neuroinflammation. A polydrug approach which contains multiple bioactive components targeting multiple pathways in AD would be more appropriate. Here we focused on a Chinese medicine (HLXL), which contains 56 bioactive natural products identified in 11 medicinal plants and displays potent anti-inflammatory and immuno-modulatory activity.Hypothesis/Purpose: We investigated the neuroimmune and neuroinflammation mechanisms by which HLXL may attenuate AD neuropathology. Specifically, we investigated the effects of HLXL on the neuropathology of AD using both transgenic mouse models as well as microglial cell-based models.Study design: The 5XFAD transgenic animals and microglial cell models were respectively treated with HLXL and AI342, and/or lipopolysaccharide (LPS), and then analyzed focusing on microglia mediated AI3 uptake and clearance, as well as pathway changes.Methods: We showed that HLXL significantly reduced amyloid neuropathology by upregulation of microgliamediated phagocytosis of AI3 both in vivo and in vitro. HLXL displayed multi-modal mechanisms regulating pathways of phagocytosis and energy metabolism.Results: Our results may not only open a new avenue to support pharmacologic modulation of neuroinflammation and the neuroimmune system for AD intervention, but also identify HLXL as a promising natural medicine for AD. Conclusion: It is conceivable that the traditional wisdom of natural medicine in combination with modern science and technology would be the best strategy in developing effective therapeutics for AD.
推荐引用方式
GB/T 7714：

Liang Yingxia,Lee David Y. W.,Zhen Sherri, et al. Natural medicine HLXL targets multiple pathways of amyloid-mediated neuroinflammation and immune response in treating alzheimer''s disease [J].PHYTOMEDICINE,2022,104.
APA：

Liang Yingxia,Lee David Y. W.,Zhen Sherri,Sun Haoqi,&Zhang Can.(2022).Natural medicine HLXL targets multiple pathways of amyloid-mediated neuroinflammation and immune response in treating alzheimer''s disease .PHYTOMEDICINE,104.
MLA：

Liang Yingxia, et al. "Natural medicine HLXL targets multiple pathways of amyloid-mediated neuroinflammation and immune response in treating alzheimer''s disease" .PHYTOMEDICINE 104(2022).
入库时间：

8/1/2022 8:26:42 PM
更新时间：

8/1/2022 8:26:42 PM
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