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Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome  期刊论文  

  • 编号:
    CE0FDB6A31E2C849E35159DF526EE37D
  • 作者:
    Shi, Yongyong(师咏勇)#[1,2,3,4]Zhao, Han(赵涵)#[5,6,7]Shi, Yuhua(石玉华)#[5,6,7]Cao, Yunxia(曹云霞)#[8]Yang, Dongzi(杨冬梓)#[9]Li, Zhiqiang(李志强)#[1,2,3]Zhang, Bo[10];Liang, Xiaoyan[11];Li, Tao;Chen, Jianhua[1,12];Shen, Jiawei[1];Zhao, Junzhao[13];You, Li[5,6,7];Gao, Xuan[5,6,7];Zhu, Dongyi[14];Zhao, Xiaoming[15];Yan, Ying[16];Qin, Yingying[5,6,7];Li, Wenjin[1];Yan, Junhao[5,6,7];Wang, Qingzhong[1];Zhao, Junli[17];Geng, Ling[5,6,7];Ma, Jinlong[5,6,7];Zhao, Yueran[5,6,7];He, Guang[1];Zhang, Aiping[1];Zou, Shuhua[18];Yang, Aijun[19];Liu, Jiayin[20];Li, Weidong[1];Li, Baojie[1];Wan, Chunling[1];Qin, Ying[21];Shi, Juanzi[22];Yang, Jing[23];Jiang, Hong[24];Xu, Jine[25];Qi, Xiujuan[25];Sun, Yun[15];Zhang, Yajie[26];Hao, Cuifang[27];Ju, Xiuqing[28];Zhao, Dongni[29];Ren, Chune(任春娥)[30]Li, Xiuqing[31];Zhang, Wei[32];Zhang, Yiwen[33];Zhang, Jiangtao[5];Wu, Di[5];Zhang, Changming[5];He, Lin(贺林)*[1,2,34,35]Chen, ZiJiang(陈子江)*[5,6,7,15]
  • 语种:
    英文
  • 期刊:
    NATURE GENETICS ISSN:1061-4036 2012 年 44 卷 9 期 (1020 - +) ; SEP
  • 收录:
  • 摘要:

    Following a previous genome-wide association study (GWAS 1) including 744 cases and 895 controls, we analyzed genome-wide association data from a new cohort of Han Chinese (GWAS 2) with 1,510 polycystic ovary syndrome (PCOS) cases and 2,016 controls. We followed up significantly associated signals identified in the combined results of GWAS 1 and 2 in a total of 8,226 cases and 7,578 controls. In addition to confirming the three loci we previously reported, we identify eight new PCOS association signals at P < 5 x 10(-8): 9q22.32, 11q22.1, 12q13.2, 12q14.3, 16q12.1, 19p13.3, 20q13.2 and a second independent signal at 2p16.3 (the FSHR gene). These PCOS association signals show evidence of enrichment for candidate genes related to insulin signaling, sexual hormone function and type 2 diabetes (T2D). Other candidate genes were related to calcium signaling and endocytosis. Our findings provide new insight and direction for discovering the biological mechanisms of PCOS.

  • 推荐引用方式
    GB/T 7714:
    Shi Yongyong,Zhao Han,Shi Yuhua, et al. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome [J].NATURE GENETICS,2012,44(9):1020-+.
  • APA:
    Shi Yongyong,Zhao Han,Shi Yuhua,Cao Yunxia,&Chen Zi-Jiang.(2012).Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome .NATURE GENETICS,44(9):1020-+.
  • MLA:
    Shi Yongyong, et al. "Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome" .NATURE GENETICS 44,9(2012):1020-+.
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