The healing of bacteria-infected wounds is often impeded by a complicated microenvironment featuring bacterial colonization, excessive inflammation, and elevated reactive oxygen species (ROS). Notably, a key feature of this microenvironment of bacteria-infected wounds is its alkaline pH (7.5-8.9), which is frequently overlooked by conventional acid-responsive therapeutics. To address this issue, we developed an effective multifunctional nanoplatform, denoted as PDA@Que@MSN(Zn), by loading quercetin (Que) onto zinc-doped and amino-modified mesoporous silica, followed by a polydopamine (PDA) coating. Crucially, the transition from acidic to neutral/alkaline of the wound microenvironment markedly accelerates the corelease of Zn2+ and Que and elevates Que's efficiency from 17.4% +/- 0.1% to 34.8% +/- 0.6%, which is further enhanced to 55.0% +/- 1.2% by the additional NIR photothermal stimulus. The combination of Que, Zn2+, and photothermal effect of PDA, significantly enhancing the overall antibacterial efficacy, achieved over 99% eradication rates against both and . Beyond its potent antimicrobial activity, the nanoplatform also exhibits excellent antioxidant and anti-inflammatory functions by effectively scavenging ROS and downregulating pro-inflammatory cytokines. Further, mouse models demonstrated effective bacterial clearance and significantly accelerated wound healing without inducing significant systemic toxicity. In summary, this work presents a smart pH/NIR-responsive nanotherapeutic strategy for the synergistic treatment of bacteria-infected wounds.
[1]Shandong Second Med Univ, Sch Pharm, Weifang 261053, Peoples R China.
[2]Shandong Engn Res Ctr Smart Mat & Regenerat Med, Weifang 261053, Peoples R China.
[3]Shandong Acad Environm Sci & Testing Co LTd, Jinan 250000, Peoples R China.
[4]Comprehens Tech Serv Ctr Weifang Customs, Weifang 261031, Peoples R China.
(8.0+极速模式)