首页 / 院系成果 / 成果详情页

STAT3 mediates ECM stiffness-dependent progression in ovarian cancer  期刊论文  

  • 编号:
    2E70D53A459B645F1ABC7077A7641759
  • 作者:
    Chenchen, Sun#[1]Xueqian, Qian[1];Yahui, Lu[1];Yi, Yuan[1];Hui, Zhang[1];Lanning, Bai[2];Min, Cheng(成敏)[3]Yangyang, Han*[1]
  • 语种:
    英文
  • 期刊:
    MOLECULAR AND CELLULAR BIOCHEMISTRY ISSN:0300-8177 2025 年 480 卷 1 期 (607 - 620) ; JAN
  • 收录:
  • 关键词:
  • 摘要:

    The treatment of ovarian cancer remains a medical challenge and its malignant progression is connected with obvious changes in both tissue and cell stiffness. However, the accurate mechanical-responsive molecules and mechanism remains unclear in ovarian cancer. Based on our previous results combined with the crucial regulatory role of STAT3 in the malignant progression of various cancer types, we want to investigate the relationship between STAT3 and matrix stiffness in ovarian cancer and further explore the potential mechanisms. Collagen-coated polyacrylamide gels (1, 6, and 60 kPa) were prepared to mimic soft or hard matrix stiffness. Western blotting, qRT-PCR, flow cytometry, IHC, EdU assays, and TEM were used to evaluate the effect of STAT3 in vitro under different matrix stiffnesses. Furthermore, a BALB/c nude mouse model was established to assess the relationship in vivo. Our results confirmed the differential expression of STAT3/p-STAT3 not only in normal and malignant ovarian tissues but also under different matrix stiffnesses. Furthermore, we verified that STAT3 was a mechanically responsive gene both in vitro and in vivo, and the mechanical response was carried out by altering the migration-related molecules (TNFAIP1) and adhesion-related molecules (LPXN, CNN3). The novel findings suggest that STAT3, a potential therapeutic target for clinical diagnosis and treatment, is a mechanically responsive gene that responds to matrix stiffness, particularly regulation in migration and adhesion in the progression of ovarian cancer.

  • 推荐引用方式
    GB/T 7714:
    Chenchen Sun,Xueqian Qian,Yahui Lu, et al. STAT3 mediates ECM stiffness-dependent progression in ovarian cancer [J].MOLECULAR AND CELLULAR BIOCHEMISTRY,2025,480(1):607-620.
  • APA:
    Chenchen Sun,Xueqian Qian,Yahui Lu,Yi Yuan,&Yangyang Han.(2025).STAT3 mediates ECM stiffness-dependent progression in ovarian cancer .MOLECULAR AND CELLULAR BIOCHEMISTRY,480(1):607-620.
  • MLA:
    Chenchen Sun, et al. "STAT3 mediates ECM stiffness-dependent progression in ovarian cancer" .MOLECULAR AND CELLULAR BIOCHEMISTRY 480,1(2025):607-620.
  • 入库时间:
    6/8/2024 10:56:59 PM
  • 更新时间:
    10/10/2024 10:00:28 PM
  • 条目包含文件:
    文件类型:PDF,文件大小:
    正在加载全文
浏览次数:23 下载次数:0
浏览次数:23
下载次数:0
打印次数:0
浏览器支持: Google Chrome   火狐   360浏览器极速模式(8.0+极速模式) 
返回顶部